HQ461 deuterium-labeled-ketone 2 SMILES: OC(=O)C1=CC=C2C(=C1)C(=O)OC21C2=CC(Cl)=C(O)C=C2OC2=C1C=C(Cl)C(O)=C2

2 SMILES: OC(=O)C1=CC=C2C(=C1)C(=O)OC21C2=CC(Cl)=C(O)C=C2OC2=C1C=C(Cl)C(O)=C2

Product Name Thalidomide-C5-Br Synonyms Thalidomide-4'-C5-Br CAS Number 2411022-24-5 Related CAS Molecular Formula C18H19BrN2O4 Molecular Weight 407

The fluorescence emission spectrum of Lissamine rhodamine B lies between those of tetramethylrhodamines and X-rhodamines

Contains cereblon ligand Thalidomid and 5'-substituted piperazine group

HQ461 deuterium-labeled-ketone 2 SMILES: OC(=O)C1=CC=C2C(=C1)C(=O)OC21C2=CC(Cl)=C(O)C=C2OC2=C1C=C(Cl)C(O)=C2HQ461 is a molecular glue that promotes CDK12 DDB1 interaction to trigger cyclin K degradation. HQ461 mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death. Product Name HQ461 Synonyms CAS Number 1226443 41 9 Related CAS Molecular Formula C15H15N5OS2 Molecular Weight 345. 44 SMILES CC1=CN=C(NC(=O)CC2=CSC(NC3=NC(C)=CC=C3)=N2)S1 Purity